Conservez nos Yeux, pas nos Collyres!   Afficher en Français  Display in English

 

 

 

Intro

Conservateurs

Conséquences

Facteurs Aggravants

Conscience des Labos

Conscience des Ophtalmologues

Quel Collyre Quel Conservateur

Alternatives

Que Faire

Témoignages

Réactions des Labos

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Contacts et Liens

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Contact et Liens 

Vous avez d'autres questions, informations, liens , références ou ... des insultes? Veuillez transmettre à keratos_contact@hotmail.com

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Logo: Keratos - Revenir au site, Back to siteKeratos est une organisation à but non lucratif basée en France, avec des délégations et membres au Portugal, en Belgique et en Norvège sur les pathologies de la surface oculaire et les dysfonctionnements lacrymaux (dont les yeux secs). Cette association, soumise au droit français, cherche à fournir de l'information et à améliorer la condition de ceux qui souffrent de pathologies de la surface oculaire. 

Cliquez sur l'image ci contre pour visiter notre site principal.

 

Nous voulons à cette occasion remercier les contributeurs à ce site Internet: Dotanne (Nouvelle-Zélande), Luísa (Portugal), Neil & Matt (EUA), Steve (Canada), Toril (Norvège). Plus généralement ce site est dédié à toutes les victimes des conservateurs oculaires.

Si vous n'êtes toujours pas convaincu par les effets négatifs des conservateurs dans les collyres ou vous souhaitez apprendre davantage sur les nombreuses conséquences des conservateurs, nous vous suggérons de lire les études suivantes.

Ci-dessous une liste de pages Internet et des Etudes sur les conservateurs:

Sites:

http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=3549&nbr=2775

http://www.iovs.org/cgi/content/full/42/3/642

http://www.iovs.org/cgi/reprint/25/12/1453.pdf

http://www.knowledgeofhealth.com/blog/2001_09_01_archive.html

http://www.ingentaconnect.com/content/mksg/cod/2005/00000052/00000006/art00008

http://www.medscape.com/viewarticle/512387_4 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16900358&query_hl=1&itool=pubmed_docsum 

http://www.optometric.com/article.aspx?article=71748 

http://www.eyeworld.org/article.php?sid=3583 

http://www.dryeyezone.com/talk/showthread.php?t=2460 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17003409&query_hl=7&itool=pubmed_docsum 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16799018&query_hl=1&itool=pubmed_docsum 

http://www.clspectrum.com/article.aspx?article=13025 

http://www.aios.org/proceed2003/External/Ext11.pdf 

http://www.medscape.com/viewarticle/512387_References 

http://www.pharmcast.com/Patents100/Yr2005/Sept2005/092705/6949241_Eye092705.htm 

http://www.chinadaily.com.cn/english/doc/2005-08/04/content_466206.htm 

http://www.iovs.org/cgi/content/abstract/47/7/2812 

http://www.revoptom.com/index.asp?ArticleType=SiteSpec&page=osc/feb01/lesson_0201.htm

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17172885&query_hl=13&itool=pubmed_docsum

http://www.ingentaconnect.com/content/tandf/orbi/1999/00000018/00000002/art00003?crawler=true

http://dev.expertsmtl.com/cme4/mediconcept/Noecker.pdf

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=7742279

http://www.ophmanagement.com/article.aspx?article=86656

Etudes:

Graefes Archive for Clinical Experimental Ophthalmology. 2006 Aug 10; Comparative study of topical anti-allergic eye drops on human conjunctiva-derived cells: responses to histamine and IFNgamma and toxicological profiles. Pauly A, Brignole-Baudouin F, Guenoun JM, Riancho L, Rat P, Warnet JM, Baudouin C. U598, INSERM, Cordeliers Biomedical Institute, 15 rue de l'ecole de medecine, 75006, Paris, France.

Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Pisella PJ, Pouliquen P, Baudouin C.APHP Ambroise Pare Hospital, University Paris V, Ophthalmology Department, 9, avenue Charles de Gaulle, 92100 Boulogne, France.

 A comparative study of the ocular tolerance after administration of anti-allergic eye drops with or without a preservative [Article in French] Beden C, Helleboid L, Marmouz F, Liard F. Societe Naxis, Lyon, France.

Comparison of the Short-Term Effects on the Human Corneal Surface of Topical Timolol Maleate With and Without Benzalkonium Chloride. Journal of Glaucoma. 12(6):486-490, December 2003. Ishibashi, Takeshi MD; Yokoi, Norihiko MD, PhD; Kinoshita, Shigeru MD, PhD.

Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man. WS Wilson, AJ Duncan and JL Jay. 1975 by the British Journal of Ophthalmology.

Preservative-free artificial tear preparations. Assessment of corneal epithelial toxic effects . G. J. Berdy, M. B. Abelson, L. M. Smith and M. A. George. Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.

Corneal toxicity secondary to inadvertent use of benzalkonium chloride preserved viscoelastic material in cataract surgery. Eleftheriadis et al. Br. J. Ophthalmol. 2002;86:299-305.

Allergy and preservatives. Apropos of 3 cases of allergy to benzalkonium chloride Chiambaretta F, Pouliquen P, Rigal D. Service d'Ophtalmologie, Hopital Gabriel-Montpied, CHRU, Clermont-Ferrand: J Fr Ophtalmol. 1997;20(1):8-16

Solving the Preservative Paradox. Better packaging for nonpreserved tears is the answer. BY HERBERT L. GOULD M.D., F.A.C.S.

Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication.P J Pisella1,2, P Pouliquen3 and C Baudouin1,4 .1 APHP Ambroise Paré Hospital, University Paris V, Ophthalmology Department, 9, avenue Charles de Gaulle, 92100 Boulogne, France. 2 Bretonneau University Hospital, Ophthalmology Department, 2, boulevard Tonnellé, 37044 Tours Cedex 1, France. 3 Théa Laboratories, 12, rue Louis-Blériot, - ZI du Brézet, 63017 Clermont-Ferrand, Cedex 2, France,4 XV-XX National Hospital, University Paris V, 28, rue de Charenton, 75012 Paris, France

Br J Ophthalmol 1998;82:39-42 ( January )Short term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers Christophe Baudouin,a Christine de Lunardob Br J Ophthalmol 1998;82:39-42 ( January )

Short term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers. Christophe Baudouin,a Christine de Lunardob a Department of Ophthalmology, Ambroise Paré, University of Paris-V René Descartes, France, b Center of Clinical Pharmacology, Pasteur Hospital, University of Nice, Francea Department of Ophthalmology, Ambroise Paré, University of Paris-V René Descartes, France, b Center of Clinical Pharmacology, Pasteur Hospital, University of Nice, France

Quaternary Ammoniums and Other Preservatives’ Contribution in Oxidative Stress and Apoptosis on Chang Conjunctival Cells Caroline Debbasch1,2, Françoise Brignole3, Pierre-Jean Pisella1,2, Jean-Michel Warnet1, Patrice Rat1 and Christophe Baudouin2 1 From the Unit of Cellular Pharmacotoxicology, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, the Toxicology Laboratory, University of Paris-V; and the 2 Ophthalmology and 3 Immunohematology Services, Hôpital Ambroise Paré, Assistance Publique–Hôpitaux de Paris, University of Paris-V, Boulogne, France.

Impact of short-term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin, So-Hyang Chung,1 Su Kyung Lee,1 Stephen M. Cristol,2 Eun Suk Lee,3 Dong Wook Lee,4 Kyoung Yul Seo,1 Eung Kweon Kim1,5.

Cha SH, Lee JS, Oum BS, Kim CD. Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro. Clin Experiment Ophthalmol 2004;32(2):180-4.

RegeneRx's TB4 Subject of Four Presentations at 2005 ARVO Meeting; Researchers Present New Data Indicating TB4 May Reduce Deleterious Effects Associated with Chronic Use of Eye Drops, Business Wire, May 2, 2005.

Investigative Ophthalmology and Visual Science. 2006 Jul; 47(7):2812-9. Fluoroquinolone eye drop-induced cytotoxicity: role of preservative in P2X7 cell death receptor activation and apoptosis.* Dutot M,* Pouzaud F, * Larosche I,* Brignole-Baudouin F,* Warnet JM,* Rat P.Laboratoire de Toxicologie, Faculte des Sciences Pharmaceutiques et Biologiques, Université Rene Descartes-Paris, and Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France.

 

Au-delà des collyres::

Call for worldwide withdrawal of benzalkonium chloride from nebulizer solutions.  Journal of Allergy and Clinical Immunology, Volume 107, Issue 2, Pages 222-223 R. Beasley

Benzalkonium chloride in a decongestant nasal spray aggravates rhinitis medicamentosa in healthy volunteers. Clin Exp Allergy.1995; 25:957-965
Benzalkonium chloride induces mucosal swelling, which explains why the presence of this preservative in a decongestant spray aggravates nasal/sinus symptoms

Effects of topical nasal steroids on human respiratory mucosa and human granulocytes in vitro. Steinsv¡ag S. Acta Otolaryngol (Stockh), 116(6):868-75 1996
"It is concluded that benzalkonium chloride has toxic effects on human respiratory mucosa and human neutrophils in vitro."

Effect of topical corticosteroids and topical antihistaminics on ciliary epithelium of human nasal mucosa in vitro. Hofmann T. HNO, 46(2):146-51 1998 Feb
"An irreversible cessation of ciliary movement was observed in all cells exposed to nasal sprays containing benzalconium chloride....." "we recommend that this preservative should not be used anymore in topical nasal medications."

The effects of topical nasal steroids on rat respiratory mucosa in vivo, with special reference to benzalkonium chloride. Berg OH. Allergy, 52(6):627-32 1997 Jun
"In conclusion, benzalkonium chloride appears to be potentially toxic to the nasal mucosa."

 

Voilà ce que nous appelons le paradoxe des conservateurs!

Conservez nos Yeux, Pas nos Gouttes!

 

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